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No large-scale, long-term human trials exist to fully understand its safety profile
On the other hand, sitagliptin is less efficacious but has fewer gastrointestinal side effects and is available by oral administration [18]
New Phytol
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Although clinical studies have not demonstrated overt systemic depletion of NAD(P) during GLP-1RA therapy, sustained reductions in nutrient inflow may influence precursor availability and turnover kinetics, particularly in metabolically stressed populations
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